Hookworm anemia, an infection underestimated by clinicians

Authors

Keywords:

hookworm infection, ancylostomiasis, iron-deficiency anemia, helminth, intestinal parasite infection.

Abstract

Hookworm infection was first described by Dubini in 1838. It is an intestinal helminth infection caused by Necator americanus and/or Ancylostoma duodenale. They are frequently endemic to tropical and subtropical areas and affect both children and adults. Transmission increases when there are socio-cultural and demographic environments that favor fecal contamination; therefore, it is a public health problem worldwide. We describe the case of a 20-year-old male patient who presented to the emergency department with asthenia, adynamia, tachycardia, and generalized mucocutaneous pallor. The blood test showed severe anemia and eosinophilia. Transfusion of 4 IU of red blood cells and ferrous sulphate was required. The coprological test showed infection by Necator americanus, which was treated with albendazole. Afterwards, the patient was discharged from the health institution. Hookworm infection is a neglected cause of gastrointestinal bleeding and anemia by the clinician. Therefore, the present study highlights this parasitosis as an important cause in the differential diagnosis. In addition, greater importance is given to preventive strategies such as training the health professionals, reinforcement of hygiene techniques, decrease of contamination and increase of proper personal hygiene.

Downloads

Download data is not yet available.

References

Rodríguez-Guardado A, Pozo E, Fernández-García R, Amo-Fernández J, Nozal-Gancedo T. Uncinariasis como causa de anemia ferropénica en población penitenciaria. Rev Esp Sanid Penit. 2013;15(2):63-5. DOI: https://doi.org/10.4321/S1575-06202013000200004

Arteaga-Livias K, Dámaso-Mata B, Rojas-García A, Rojas-Inga I, Panduro-Correa V, Rodríguez-Bravo P. Anemia severa en adulto joven con infección por uncinarias. Rev Cubana Med Trop. 2020 [acceso 10/01/2022];72(1):1-9. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1126704

Caicedo AJC, Bravo JEG, Cedeño JJU, Ochoa YAR. Valores de laboratorio clínico en adultos con diagnóstico de Uncinariasis. Dominio de las Ciencias. 2021;7(4):1503-20. DOI: http://dx.doi.org/10.23857/dc.v7i4

Pizza-Restrepo J, Mosquera-Klinger GA. Diagnóstico endoscópico de Uncinariasis, presentación de un caso con anemia ferropénica grave. Rev. colomb. Gastroenterol. 2019 [acceso 21/01/2022];34(4):433-7. Disponible en: https://revistagastrocol.com/index.php/rcg/article/view/289

Vargas Rodríguez LJ, Rozo Ortiz EJ, Szemmelveisz ET, Jimenez WJP. Uncinariasis: una causa poco común de anemia severa. Rev. colomb. Gastroenterol. 2019 [acceso 05/02/2022];34(3):303-6. Disponible en: https://revistagastrocol.com/index.php/rcg/article/view/250

Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, et al. The Global Economic and Health Burden of Human Hookworm Infection. PLoS Negl Trop Dis. 2016;10(9):24-9. DOI: https://doi.org/10.1371/journal.pntd.0004922

Alemu M, Kinfe B, Tadesse D, Mulu W, Hailu T, Yizengaw E. Intestinal parasitosis and anaemia among patients in a Health Center, North Ethiopia. BMC Res Notes. 2017;10(1):632. DOI: https://doi.org/10.1186/s13104-017-2957-2

Degarege A, Yimam Y, Madhivanan P, Erko B. The relationship between helminth infections and low hemoglobin levels in Ethiopian children with blood type A. J Helminthol. 2017;91(3):278-83. DOI: https://doi.org/10.1017/S0022149X16000286

Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. N Engl J Med. 2004;351(8):799-807. DOI: https://doi.org/10.1056/NEJMra032492

Srygley FD, Gerardo CJ, Tran T, Fisher DA. Does this patient have a severe upper gastrointestinal bleed? JAMA. 2012;307(10):1072-9. DOI: https://doi.org/10.1001/jama.2012.253

Carrada-Bravo T. Monografías ilustradas de patología clínica. Uncinariasis: ciclo vital, cuadros clínicos, patofisiología y modelos animales. Rev Mex Patol Clin Med Lab. 2007;54(4):187-99.

Fernández-Rivas G, Rivaya B, Romaní N, Hao Wang J, Alcaide M, Matas L. Diagnosis of soil-transmitted helminth infections. An unsolved problemin the omics era. Enfermedades Infecciosas y Microbiología Clínica (English ed.). 2019;37(Suppl)1:20-25. DOI: https://doi.org/10.1016/s0213-005x(19)30178-8 PMID: 31138419.

Grimes JET, Tadesse G, Gardiner IA, Yard E, Wuletaw Y, Templeton MR, et al. Sanitation, hookworm, anemia, stunting, and wasting in primary school children in southern Ethiopia: Baseline results from a study in 30 schools. PLoS Negl Trop Dis. 2017;11(10):e0005948. DOI: https://doi.org/10.1371/journal.pntd.0005948

Gonzales E, Huamán-Espino L, Gutiérrez C, Aparco JP, Pillaca J. Caracterización de la anemia en niños menores de cinco años de zonas urbanas de Huancavelica y Ucayali en el Perú. Rev Peru Med Exp Salud Pública. 2015 [acceso 11/02/2022];32(3):431-9. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342015000300004&lng=es

Marcos Raymundo LA, Maco Flores V, Machicado A, Samalvides Cuba F, Terashima Iwashita A, Quijano C, et al. Diferencias de prevalencia de parasitosis intestinal entre los hospitales Militar y Regional de Iquitos, Loreto-Perú. Diagnóstico (Perú). 2002 [acceso 11/02/2022];185-7. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/lil-322578

Nutman TB, Ottesen EA, Ieng S, Samuels J, Kimball E, Lutkoski M, et al. Eosinophilia in Southeast Asian refugees: evaluation at a referral center. J Infect Dis. 1987;155(2):309-13. DOI: https://doi.org/10.1093/infdis/155.2.309 PMID: 3805765

Serre-Delcor N, Treviño B, Monge B, Salvador F, Torrus D, Gutiérrez-Gutiérrez B, et al. Eosinophilia prevalence and related factors in travel and immigrants of the network +REDIVI. Enferm Infecc Microbiol Clin. 2017;35(10):617-23. DOI: https://doi.org/10.1016/j.eimc.2016.02.024 Epub 2016 Mar 28

Chapman PR, Giacomin P, Loukas A, McCarthy JS. Experimental human hookworm infection: a narrative historical review. PLoS Negl Trop Dis. 2021 Dec 9;15(12):e0009908. DOI: https://doi.org/10.1371/journal.pntd.0009908

Caicedo AJC, Bravo JEG, Cedeño JJU, Ochoa YAR. Valores de laboratorio clínico en adultos con diagnóstico de Uncinariasis. Dominio las Cienc. 2021 [acceso 15/02/2022];7(4):116. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8383964

Mbong Ngwese M, Prince Manouana G, Nguema Moure PA, Ramharter M, Esen M, Adégnika AA. Diagnostic Techniques of Soil-Transmitted Helminths: Impact on Control Measures. Tropical Medicine and Infectious Disease 2020;5:93. DOI: https://doi.org/10.3390/tropicalmed5020093

Moser W, Schindler C, Keiser J. Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis. BMJ. 2017;358:j4307. DOI: https://doi.org/10.1136/bmj.j4307

Centers for Disease Control and Prevention (CDC). Biosafety in Microbiological and Biomedical Laboratories. 6th edition; 2020.

Centers for Disease Control and Prevention (CDC). Parasites-Hookworm; 2020.

Published

2023-08-13

How to Cite

1.
Vargas Rodríguez LJ, Holguín Barrera ML, García Agudelo L, Fuentes Rodríguez N, Pacheco Olmos BS, Velasco Castro JC. Hookworm anemia, an infection underestimated by clinicians. Rev Cuba Med Tropical [Internet]. 2023 Aug. 13 [cited 2025 Feb. 23];75(1). Available from: https://revmedtropical.sld.cu/index.php/medtropical/article/view/938

Issue

Section

Presentaciones de casos

Most read articles by the same author(s)