Behavior of inflammatory markers in patients diagnosed with COVID-19
Keywords:
COVID-19, ProtCR, LDH, INL, Ferritina.Abstract
Introduction: In December 2019, an outbreak of interstitial pneumonia caused by a new coronavirus (SARS-CoV-2) was reported in the city of Wuhan (China), characterized by a wide spectrum of clinical forms of presentation. It is necessary to identify those patients with a higher probability of developing complications for their prevention. The neutrophil/lymphocyte ratio (NLR), C-reactive protein (ProtCR), the enzyme lactate dehydrogenase (LDH) and ferritin have taken interest as Serum biomarkers to define severity.
Objective: Describe the behavior of inflammatory markers in patients infected with SARS-CoV-2 at the Pedro Kouri Institute of Tropical Medicine, and analyze their possible correlation with clinical severity during SARS-CoV-2 infection.
Method: A retrospective cross-sectional study was carried out, where the records of 94 patients admitted to the Pedro Kouri Institute were reviewed, including the inflammatory markers described above. The patients were divided into 2 groups according to the severity of their evolution.
Results: 50 samples from severe patients and 44 samples from mild and moderate patients were analyzed. An increase in inflammatory markers (ProtCR, LDH, INL, Ferritin) was observed, predominantly in the group of patients with severe evolution, with a peak of elevation in the second week.
Conclusions: This work confirms the importance of using inflammatory markers as a routine laboratory test in patients with suspected COVID-19 and in those diagnosed with the disease.
Downloads
References
Informe de situacion de la COVID - 19. In: Salud OPdl, editor. Disponible en: www.paho.orgSeptiembre 2022.
Protocolo de actuacion nacional para la COVID-19. In: Salud Publica Md, editor. Version 6.2021.
García-Zuluaga G, Gil-Murillo D, Nieto-Cárdenas OA. Comportamiento del virus COVID-19 en una unidad de cuidados intensivos. Acta Colombiana de Cuidado Intensivo. 2023.
Mosquera‐Sulbaran J, Pedreañez A, Carrero Y, Callejas D. C‐reactive protein as an effector molecule in Covid‐19 pathogenesis. Rev Med Virol 2021;31(6).
Khadzhieva MB, Gracheva AS, Belopolskaya OB, Chursinova YV, Redkin IV, Pisarev MV, et al. Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients. Diagnostics. 2023;13(4):746.
Vaquero-Ronceroa LM, Sánchez-Barradoa E, Escobar-Maciasa D, Arribas-Péreza P, González de Castrob R, González-Porrasc JR. Proteína C reactiva y escala SOFA: una simple escala como factor predictivo temprano de la necesidad de cuidados críticos en los pacientes con neumonía causada por COVID-19 en Espa˜na. Revista Española de Anestesiología y Reanimación. 2021;68 513---22.
Bhat K, Ahmad S. Biochemical Markers of COVID -19: Role in Diagnosis, Management and Predicting Severity of the Disease. International Journal of Innovative Research in Medical Science. 2023;8(02):53 - 7.
Du RH, Liang LR, Yang CQ, Wang W, Cao TZ, Li M, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. . European Respiratory Journal, . 2020;55(5): 2000524.
Ruiz Sagastume C. Inflammatory markers and severity of COVID-19. Revista Diversidad Científica. 2022;2 (2).
Procedimientos Normalizados de Operacion (PNO, (1998).
Fan BE, Lian Chong VC, Wei Chan SS, Lim GH, Eric Lim KG, Tan GB, et al. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020;95(6):E131-4.
Poggiali E, Zaino D, Immovilli P, Rovero L, Losi G, Dacrema A, et al. Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clin Chim Acta. 2020;509:135-8.
Ysabel Lozano Y, Palacios E. Factors associated with the hospitalization of COVID-19 patients in a clinic’s intensive care unit in 2020. Horiz Med. 2021;21(1):e1379.
Ballou SP, I. K. Laboratory evaluation of inflammation. In: Ruddy S HE, Sledge CB,, editor. Kelley’s Textbook of Rheumatology Philadelphia: JB Saunders Company;; 2001. p. 697-703.
Wilson PW, Nam BH, Pencina M, D’agostino RB, Benjamin EJ, CJ. Od. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med 2005 165(21):2473-8.
Pérez G. ¿Es la comorbilidad cardiovascular la causante de la elevación de la proteína C reactiva en pacientes positivos a la COVID-19? Acta Médica del Centro 2020;14 (3 ).
Aloisio E, Colombo G, Dolci A, Panteghini M. C-reactive protein and clinical outcome in COVID-19 patients: the importance of harmonized measurements. Clinical Chemistry and Laboratory Medicine (CCLM). 2023.
Jiangshan L, Ciliang J, Shaorui H, Xiaoli Z, Meifang Y, Xi J, et al. High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study. . Aging. 2020;12(14):13849-59.
Montalvo M, González C. The neutrophiles/lymphocytes index: is a predictor of mortality in a patient with infection by SARS-CoV-2. Med Crit 2021;35(3):130-5.
Basbus L, Lapidus M, Martingano I, Puga M, Pollán J. Índice Neutrófilo-linfocito como factor pronóstico de COVID-19. Medicina Intensiva. 2020;80 (III):31-6.
Escobar-Salinas J, Sobarzo-Vysokolan P. Neutrophil-lymphocyte index as a predictor of the development of severe pneumonia due to SARS-CoV-2 in the Hospital Nacional, Itauguá. Rev virtual Soc Parag Med Int. 2022;9(1):55-61.
Aparicio-Ramítez J. Indice neutrófilo/linfocito como predictor severidad en pacientes con sospecha de COVID 19 en el Hospital General de zona IMSS 1 de Aguascalientes. Aguascalientes : Universidad Autónoma de Aguascalientes, Centro de Ciencias de la Salud, Instituto Mexicano del Seguro Social. 2021.
Labrada M, Rosana L, Martínez L. Niveles de Ferritina Como Signo de Agravamiento en los Pacientes con COVID 19. Segundo Congreso Virtual de Ciencias Basicas Y Biomedicas, Gramma: 2021.
González R, Acosta F, Evián Oliva E, Rodríguez S, Cabeza I. Predictores de mal pronóstico en pacientes con la COVID-19. Revista Cubana de Medicina Militar. 2020;49(4):e0200918.
Venegas R, Serrano A, Peña R, Santana R, Rittoles A, Grecesqui I. El tratamiento con Jusvinza disminuye la hiperinflamación y la hipercoagulación en pacientes críticos con la COVID-19. Revista Cubana de Medicina Militar. 2021;50(4):e02101675.
Taboada M, Rama P, Pita-Romero R, Moreno E, Leal S, Varela M, et al. Pacientes críticos COVID-19 atendidos por anestesiólogos en el Noroeste de España: estudio multicéntrico, prospectivo, observacional. Revista Española de Anestesiología y Reanimación,. 2021;68(1):10-20. .
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Juan Mario Junco Rodriguez
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Licencia Creative Commons
La Revista Cubana de Medicina Tropcial se encuentra bajo una
Este sitio está bajo Licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.
