Laboratory markers associated with the persistence detection of SARS-CoV-2
Keywords:
persistence, laboratory markers, SARS-CoV-2.Abstract
Introduction: The prolonged persistence of SARS-CoV-2 in the nasopharyngeal tract in some patients was one of the primary challenges posed by the virus.
Objectives: To determine the relationship between laboratory markers in COVID-19 patients and the persistence detection of SARS-CoV-2 in the nasopharynx.
Methods: It was conducted a retrospective observational study of patients with a SARS-CoV-2 positive PCR. The control group comprised patients with one positive PCR followed by two negative results, while the case group consisted of patients with at least three consecutive positive PCR tests. The time interval between consecutive samples ranged from 5 to 20 days, and only patients with SARS-CoV-2 negative serology were included. Data on demographics, comorbidities, symptoms, radiology, hospitalization, laboratory analyses, and gasometry were collected.
Results: The control group exhibited higher CT values compared to the case group, irrespective of symptoms, radiological patterns, or the PCR equipment used. Patients with persistent detection showed higher percentages of monocytes and lower percentages of lymphocytes, as well as elevated levels of amylase, C-reactive protein, and D-dimer. The deoxyhemoglobin fraction values in venous gasometry were higher in the case group; while oxyhemoglobin, oxygen saturation and partial oxygen pressure values were lower.
Conclusions: Some laboratory markers could be associated with the prolonged detection of SARS-CoV-2 in the nasopharynx, facilitating resource optimization in the laboratory and the proper planning of socio-sanitary measures.
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