Characteristics of Vaccinated Healthcare Workers Infected with SARS-CoV-2: Study at Institute “Pedro Kourí”, 2021
Keywords:
COVID-19 symptomatic disease; SARS-CoV-2 infection; vaccination; health care workers; CubaAbstract
Objective: To describe the characteristics of vaccinated and unvaccinated HCWs with SARS-CoV-2 infection, a cross-sectional study was conducted at the Pedro Kourí Tropical Medicine Institute in 2021.
Methods: Age, sex, occupation, presence of chronic disease(s), presence of symptoms, date of onset of symptoms, clinical course of illness, and vaccination status were analyzed. The vaccinated and unvaccinated cases were described and compared based on sociodemographic, clinical, and epidemiological characteristics. The data was processed in frequency, ratio, percentages, mean, and prevalence ratio with 95% confidence intervals was estimated.
Results: A total of 207 cases (81.15% fully vaccinated, 1.93% partially vaccinated, and 16.90% unvaccinated), were studied. The highest incidence of cases occurred in August, which coincided with the widespread circulation of the Delta variant. The mean age of those infected was 35 years. The infection prevailed in women (77.29%) and support staff (55.55%). Of the cases, 33.81% had previous comorbidities, of which arterial hypertension (55.71%) prevailed. There was higher frequency of mild symptoms (78%) among vaccinated cases compared to unvaccinated cases (49%). Severe symptoms only developed in three (8%) unvaccinated cases, while vaccinated cases did not develop any severe symptoms at any time. No relation was found between vaccination status and symptomatic disease (PR=0.75; IC 0.59-0.95).
Conclusions: The symptomatic cases were mild and no severe events or fatalities due to COVID-19 were reported among IPK workers during the study period.
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References
1. Chemali S, Mari-Sáez A, El Bcheraoui C, Weishaar H. Health care workers’ experiences during the COVID-19 pandemic: a scoping review. Hum Resour Health. 2022. DOI: https://doi.org/10.1186/s12960-022-00724-1
2. Mushtaq H, Singh S, Mir M, Tekin A, Singh R, Lundeen J, et al. The Well-Being of Healthcare Workers During the COVID-19 Pandemic: A Narrative Review. Cureus 2022;14(5):e25065. DOI: https://doi.org/10.7759/cureus.25065
3. Gamboa Y, Lugo M, García A, Dominguez B, González D. Challenges of Cuban Biotechnology in the fight against COVID-19. INFODIR. 2021 [acceso 19/06/2023];(33). Disponible en: http://www.revinfodir.sld.cu/index.php/infodir/article/view/883/1199
4. Hernández F, Ricardo MC, Martín Y, Rodríguez E, Urrutia Klaudia, Urrutia Karen, et al. A phase 3, randomised, double-blind, placebo-controlled clinical trial for adult evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine (ABDALA-3 Study). mexRxiv. 2022. DOI: https://doi.org/10.1101/2022.09.08.22279690
5. Toledo ME, García M, Valenzuela C, Baldoquin W, Martínez M, Rodríguez M, et al. Safety and efficacy of the two doses conjugated protein-based SOBERANA 02 COVID-19 vaccine and of a heterologous three-doses combination with SOBERANA- Plus: a double-blind, randomised, placebo-controlled phase 3 clinical trial. The Lancet Regional Health-Americas. 2023;18:100423. DOI: https://doi.org/10.0116/j.lana.2022.100423
6. Guzmán MG, Pérez L, Tejero Y, Mederos Y, Aguado ME, Pintos Y, et al. Emergence and evolution of SARS-CoV-2 genetic variants during the Cuban epidemic. J Clin Virol Plus. 2022;2(4):100104. DOI: https://doi.org/10.1016/j.jcvp.2022.100104
7. Portal JA. Health intervention with vaccine candidates, as a temporary strategy to deal with COVID-19, Cuba, 2021. Cuban Journal of Public Health. 2022;48(1). Disponible en: https://revsaludpublica.sld.cu/index.php/spu/article/view/3513
8. Ministry of Public Health of Cuba. National action protocol for covid-19. Version 1.6. Havana; 2021 [acceso 07/04/2022]. Disponible en: https://covid19cubadata.github.io/protocolos/protocolo-version-6.pdf
9. World Health Organization. COVID-19 Case definition; 2022 [acceso 22/06/2023]. Disponible en: https://www.who.int/publications/i/item/WHO-2019-nCoV-Surveillance_Case_Definition-2022.1
10. World Health Organization. Laboratory biosafety guidance related to coronavirus disease 2019 (COVID-19): interim recommendations; 2020 [acceso 13/07/2023]. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/331138/WHO-WPE-GIH-2020.1-eng.pdf
11. World Health Organization. Health Workforce Department– Working Paper 1. The impact of COVID-19 on health and care workers: a closer look at deaths. Geneva: WHO; 2021 [acceso 30/06/2022]. Disponible en: https://www.who.int/publications/i/item/WHO-HWF-WorkingPaper-2021.1
12. Pan American Health Organization. COVID-19 has infected some 570,000 health workers and killed 2,500 in the Americas. Washington DC, PAHO September 2; 2020 [acceso 22/06/2022]. Disponible en: https://www.paho.org/en/news/2-9-2020-covid-19-has-infected-some-570000-health-workers-and-killed-2500-americas-paho
13. Reyes MC, Rodríguez S, Cruz M, Díaz Y, Sánchez C, Garcés A, et al. Intervention study with SOBERANA® in the workers of the Centro Nacional de Biopreparados. Vaccimonitor. 2022 [acceso 07/09/2023];31(2):43-53. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-028X2022000200043&lng=es
14. Jorgensen P, Schmid A, Sulo J, Preza I, Hasibra I, Kissling E, et al. Factors associated with receipt of COVID-19 vaccination and SARS-CoV-2 seropositivity among healthcare workers in Albania (February 2021-June 2022): secondary analysis of a prospective cohort study. The Lancet Regional Health-Europe 2023;27:100584 DOI: https://doi.org/10.1016/j.lanepe.2023. 100584
15. Dahie A, Mohamoud H, Adam H, Garba B, Dirie I, Nur A, et al. COVID-19 Vaccine Coverage and Potential Drivers of Vaccine Uptake among Healthcare Workers in SOMALIA: A Cross-Sectional Study. Vaccines. 2022;10,1116. DOI: https://doi.org/10.3390/vaccines10071116
16. Rojkovich B, Németh D, Dinya E, Nagy E, Török E, Lázár I, et al. COVID-19 infections and effectiveness of the vaccination among healthcare workers. Orv Hetil. 2023;164(5):163-71. DOI: https//doi.org/10.1556/650.2023.32.709
17. Salhotra R, Tyagi A, Minz E E, Chaudhary P, Singh D, Toppo V. COVID-19 Vaccination Among Healthcare Workers: Trend and Protection in a Tertiary Care Hospital in Northern India. Cureus 2023 Mar;15(3):35777. DOI: https//doi.org/10.7759/cureus.35777
18. Contreras DT, Mejía H. SARS-COV-2 Infection in health workers at the Ovidio Aliaga Uria Children´s Hospital. Rev. Med. La Paz. 2021 [acceso 27/06/2022];27(1):21-7. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1726-89582021000100004&lng=es
19. Saint-Pierre G, Silva F, Conei D, Cifuentes M. Epidemiological characterization of infection by SARS-CoV-2 of the healthcare workers of a university hospital in Santiago de Chile. Rev. chil. Infectol. 2021;38(2):144-151. DOI: http://dx.doi.org/10.4067/S0716-10182021000200144
20. Chacón BD, Ortiz SJC, Ochoa TI, et al. COVID-19 behavior in health workers from Holguin Province, Cuba. March-June 2020. Correo Científico Médico. 2020 [acceso 20/06/2022];24(3):937-50. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=98243
21. Ron M. Some reflections about the impact of COVID-19 infection on healthcare workers. Salud trab. 2020 [acceso 30/06/2022];28(2):161-5. Disponible en: http://servicio.bc.uc.edu.ve/multidisciplinarias/saldetrab/vol28n2/art06.pdf
22. Molina MC, Vázquez M. Sociodemographic differentials of COVID-19 in Cuban youth. Revista Novedades en Población. 2021 [acceso 22/06/2022];17(33):348-69. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-40782021000100348&lng=es&tlng=es
23. Chico P, Gras P, Mora JG, Algado N, Sánchez J, Llorens P. Impact of the COVID-19 pandemic on health workers in the emergency department of a tertiary hospital. Emergencies. 2020 [acceso 22/06/2022];32:227-32. Disponible en: https://serviciopediatria.com/wp-content/uploads/2020/10/2020_Impacto-pandemia-COVID-19-en-trabajadores-servicios-de-urgencias_Emergencias.pdf
24. Hierrezuelo N, Fernández P, León A, Johnson S, Cordero F. Main clinical and epidemiological characteristics of health workers diagnosed with COVID-19 in Santiago de Cuba. MEDISAN. 2021 [acceso 20/06/2022];25(6):1-11. Disponible en: https://www.redalyc.org/journal/3684/368469640004/
25. Medina LF, Quintanilla GJ, Juárez I, Shafick J. Occupational exposure to COVID-19 in healthcare workers from Latin America, may 2020. Rev Cient Cienc Méd. 2020 [acceso 28/06/2022];23(2):214-20. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1817-74332020000200012&lng=es
26. Plasencia TM, Aguilera R, Almaguer LE. Comorbilidades y gravedad clínica de la COVID-19: revisión sistemática y meta-análisis. Rev haban cienc méd. 2020 [acceso 06/12/2023];19(Suppl 1):e3389. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2020000400002&lng=es
27. Kim SR, Kang HJ, Jeong HR, Jang SY, Lee JE, Kim DE, et al. Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination. J Korean Med Sci. 2022 Sep 5;37(35):e267. DOI: https://doi.org/10.3346/jkms.2022.37.e267
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Copyright (c) 2026 Elba Cruz Rodríguez, Niurka Molina Águila, Waldemar Baldoquin Rodríguez, Madelyn Garcés Martínez, Jorge Fraga Nodarse, Ana Margarita Gascón Fernández, Miguel Angel Acosta Suárez, Reinaldo León Canga, María Guadalupe Guzmán Tirado, Vivian Kourí Cardellá
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