Free living Amoebae: "Trojan horses" or vectors in the dissemination of Helicobacter pylori in aquatic environments?
Keywords:
Free living Amoebae, Helicobacter pylori, antimicrobial resistance, bacterial persistence.Abstract
Introduction: Free living amoebae are unicellular eukaryotic microorganisms that are found in different environments and that interact with bacteria, viruses and fungus. Recently, it has called the attention of the scientific community the established relation between free living amoebae and Helicobacter pylori.
Objectives: To update the role of free-living amoebae in the dissemination of Helicobacter pylori, as well as to clarify how this phenomenon can influence in the bacterial persistence, and in its possible resistance to antimicrobials.
Methods: Different search engines such as Google, PubMed, Cochrane, Google Scholar, SciELO, Redalyc, among others were used. The search was limited to the last 10 years, although some older studies, mainly classics, were taking into consideration.
Conclusions: The updating of the topic back up the fact that free living amoebae, specially Acanthamoeba spp. in the aquatic environments, intervene as Helicobacter pylori reservoir and acts as "Trojan horses” for the persistence and the dissemination of this bacteria, considered resistant to antimicrobials, specially clarithromycin and a causal agent of several gastroduodenal diseases, for instance, gastric cancer. Future investigations focused on medullar aspects of the physiopathology of this relation between both microorganisms, should be projected for a better knowledge and level of acting in front of what can be considered a serious health problem.
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